For more information on CUPRIMINE and SYPRINE, please see below:


CUPRIMINE® (penicillamine) is used to treat Wilson's disease (a disease where there is too much copper in the body), cystinuria (a disease where an excess amount of certain proteins are in the urine) and patients with severe, active rheumatoid arthritis who have not had a response to other therapy. The available evidence suggests that CUPRIMINE is not effective for the treatment of ankylosing spondylitis.

Important Safety information

WARNING: You should be under the close supervision of your doctor when you are taking CUPRIMINE. Report any side effects promptly to your doctor.

Do not take CUPRIMINE if you have cystinuria or rheumatoid arthritis and are pregnant. If you are taking CUPRIMINE to treat Wilson’s disease, the potential risks of continuing your treatment to your baby during pregnancy should be discussed with your healthcare provider. Reported experience shows that continued treatment with CUPRIMINE throughout pregnancy protects you against relapse of Wilson’s disease. Stopping your CUPRIMINE treatment during pregnancy could have negative effects which could be fatal. Mothers on therapy with CUPRIMINE should not nurse their infants. Tell your healthcare provider if you are pregnant or plan to become pregnant. Promptly report to your healthcare provider any missed menstrual periods or other indications of possible pregnancy.

CUPRIMINE can cause serious blood disorders, and some can be fatal. If you have had aplastic anemia (anemia due to lack of all blood cells) or agranulocytosis (lack of certain white blood cells) and it was related to taking CUPRIMINE, you should not take it again.

CUPRIMINE can cause kidney damage and should not be used to treat rheumatoid arthritis if you have a history of kidney disease. If you take CUPRIMINE to treat cystinuria or Wilson’s disease, routine analysis of your urine may be necessary, and you should have an x-ray every year to check for kidney stones.

CUPRIMINE can be associated with fatalities due to other diseases such as aplastic anemia, agranulocytosis, thrombocytopenia, Goodpasture’s syndrome (an immune disease that attacks the lungs and kidneys) and myasthenia gravis (an immune disease affecting the muscles).

Your doctor may order blood tests on a regular basis.

CUPRIMINE can affect how your liver works. Tests to determine how your liver is working should be done regularly.

Tell your doctor right away if you experience: blood in your urine, unexplained cough or wheezing, coughing up blood, shortness of breath, muscle weakness, drooping eyelids, double vision, watery blisters on the skin or other rash, fever, sore throat, chills, bruising, bleeding, joint pain, swollen lymph nodes, mouth ulcers, or diminished taste.

CUPRIMINE is a drug that has many side effects, and some can be fatal. Common side effects that can occur include anorexia (loss of appetite), epigastric (upper abdominal) pain, nausea, vomiting, and diarrhea, mouth ulcers, and loss of taste; serious lung problems; blood problems; nervous system symptoms such as visual loss (optic neuritis) or ear (tinnitus) symptoms, visual and psychic disturbances, mental disorders, agitation and anxiety or muscle weakness; diseases of the skin and mucous membranes, hair loss or alopecia; allergic reactions (including a condition known as drug fever and skin rashes), mouth ulcers, and loss of taste. Talk to your doctor if you experience side effects and also about possible side effects that could occur. Ask your doctor or pharmacist for product labeling written for professionals for a full list of potential side effects.

Tell your doctor if you are allergic to penicillin.

Tell your doctor about all other medicines (prescription and over-the-counter, including vitamins and herbal supplements) that you are taking. Some medicines (such as gold therapy, antimalarial or cancer drugs, oxyphenbutazone or phenylbutazone) should not be used with CUPRIMINE because they also may cause serious liver, kidney, and blood side effects.

Please click here for full Prescribing Information for CUPRIMINE including Boxed Warning.

You are encouraged to report negative side effects of prescription drugs to FDA. Visit or call 1-800-FDA-1088. You may also contact Bausch Health Customer Service at 1-800-321-4576.


SYPRINE® (trientine hydrochloride) is used to treat Wilson's disease in patients who cannot take the medication known as penicillamine. Wilson's disease is a condition where the body stores too much copper. Unlike penicillamine, SYPRINE is not recommended to treat cystinuria or rheumatoid arthritis because it is not effective in these conditions.

Important Safety information

Do not take SYPRINE if you are allergic to it.

You should remain under regular medical supervision the entire time you are taking SYPRINE.
Your doctor should regularly check to see if you have iron deficiency anemia. This is particularly important for women. Your doctor should also check for free copper in your blood.

Take SYPRINE on an empty stomach, at least one hour before a meal or two hours after a meal and at least one hour apart from any other drug, food, or milk. The capsules should be swallowed whole with water and should not be opened or chewed.

Because of the potential for contact dermatitis (inflammation of the skin), any site of exposure to the capsule contents should be washed with water promptly.

For the first month of treatment, take your temperature every night, and report any symptom such as fever or skin rash to your doctor.

Do not take mineral supplements because they may block the absorption of SYPRINE.

Tell your doctor if you are pregnant, plan to become pregnant, or are nursing.

The following adverse reactions have been reported from a clinical study: iron deficiency and a condition affecting the immune system known as systemic lupus erythematosus. In addition, the following adverse reactions have been reported in marketed use: abnormal or uncontrolled muscle contractions, muscle spasm and an immune disease affecting muscles known as myasthenia gravis.

Please click here for full Prescribing Information for SYPRINE.

You are encouraged to report negative side effects of prescription drugs to FDA. Visit or call 1-800-FDA-1088. You may also contact Bausch Health Customer Service at 1-800-321-4576.