What is Wilson’s Disease?

Wilson’s disease is a rare disease and only affects about 1 in 30,000 people around the world. Normally, copper is absorbed through food and the liver helps get rid of the excess, but in people with Wilson’s disease, the liver doesn’t eliminate extra copper as it should. This causes copper to build up in the liver, brain, and other organs, which can cause life-threatening damage over time.

WD Rx Access Program

The WD Rx Access program offers financial assistance, medication home delivery and nurse coaching for eligible* commercially insured patients. Learn more about how the WD Rx Access program may help you.

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With the WD Rx Access quarterly newsletter, The Word on Wilson’s, you can receive important program updates and helpful information about living with Wilson’s disease straight to your inbox.

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*The WD Rx Access copay savings program is only valid for individuals with commercial insurance. The WD Rx Access copay savings program is not valid for any person eligible for reimbursement of prescriptions, in whole or in part, by any federal, state, or other governmental programs, including, but not limited to, Medicare (including Medicare Advantage and Part A, B, and D plans), Medicaid, TRICARE, Veterans Administration or Department of Defense health coverage, CHAMPUS, the Puerto Rico Government Health Insurance Plan or any other federal or state health care programs. These patients may qualify for alternative financial assistance. These offers are good only in the United States of America (including the District of Columbia, Puerto Rico and the U.S. Virgin Islands). These offers are not available for individuals who live in Massachusetts and/or who have insurance coverage for prescriptions in Massachusetts. California residents and/or individuals who have insurance coverage for prescriptions in California may not be eligible to participate in the program unless they have a prior authorization or are otherwise eligible under California law. These offers are only good for use with SYPRINE® or CUPRIMINE®. No other purchase necessary. These offers are not health insurance. The patient agrees not to seek reimbursement for all or any part of the benefit received through one of these offers and is responsible for making any required reports of his/her use of one these offers to any insurer or any third party who pays any part of this prescription filled. Patients must be 18 years of age or older to redeem these offers. These offers are not transferable. These offers are not valid with other offers. These offers have no cash value. The patient is responsible for paying the first $5 for each eligible prescription fill. There is a maximum benefit for the program, and the patient is responsible for all additional costs and expenses after the maximum benefit limit is reached. The patient understands and agrees to comply with the terms and conditions of these offers. Program term eligibility expires December 31, 2021. Bausch Health reserves the right to rescind, revoke, terminate, or amend these offers at any time, with or without notice. For more information, call a WD Rx Access representative at 888-607-7267.

For more information on WD Rx Access and
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you’ve been prescribed:


CUPRIMINE® (penicillamine) is used to treat Wilson's disease (a disease where there is too much copper in the body), cystinuria (a disease where an excess amount of certain proteins are in the urine) and patients with severe, active rheumatoid arthritis who have not had a response to other therapy. The available evidence suggests that CUPRIMINE is not effective for the treatment of ankylosing spondylitis.


WARNING: You should be under the close supervision of your doctor when you are taking CUPRIMINE. Report any side effects promptly to your doctor.

  • Do not take CUPRIMINE if you have cystinuria or rheumatoid arthritis and are pregnant. If you are taking CUPRIMINE to treat Wilson’s disease, continuing your treatment during pregnancy protects you against relapse of Wilson’s disease. Stopping your penicillamine treatment during pregnancy could have negative effects which could be fatal. Mothers on therapy with penicillamine should not nurse their infants. Tell your healthcare provider if you are pregnant or plan to become pregnant.
  • CUPRIMINE can cause serious blood disorders, and some can be fatal. If you have had aplastic anemia (anemia due to lack of all blood cells) or agranulocytosis (lack of certain white blood cells) and it was related to taking CUPRIMINE, you should not take it again.
  • CUPRIMINE can cause kidney damage and should not be used to treat rheumatoid arthritis if you have a history of kidney disease. If you take CUPRIMINE to treat cystinuria or Wilson’s disease, routine analysis of your urine may be necessary, and you should have an x-ray every year to check for kidney stones.
  • CUPRIMINE can be associated with fatalities due to other diseases such as aplastic anemia, agranulocytosis, thrombocytopenia, Goodpasture’s syndrome (an immune disease that attacks the lungs and kidneys) and myasthenia gravis (an immune disease affecting the muscles).
  • Your doctor may order blood tests on a regular basis.
  • CUPRIMINE can affect how your liver works. Tests to determine how your liver is working should be done regularly.
  • Tell your doctor right away if you experience: blood in your urine, unexplained cough or wheezing, coughing up blood, shortness of breath, muscle weakness, drooping eyelids, double vision, watery blisters on the skin or other rash, fever, sore throat, chills, bruising, bleeding, joint pain, swollen lymph nodes, mouth ulcers, or diminished taste.
  • CUPRIMINE is a drug that has many side effects, and some can be fatal. Common side effects that can occur include nausea, vomiting, and diarrhea, serious lung problems, blood problems, nervous system symptoms such as eye or ear symptoms or muscle weakness, diseases of the skin and mucous membranes, allergic reactions (including a condition known as drug fever as well as skin rashes), mouth ulcers, and loss of taste. Talk to your doctor if you experience side effects and also about possible side effects that could occur. Ask your doctor or pharmacist for product labeling written for professionals for a full list of potential side effects.
  • Tell your doctor about all other medicines (prescription and over-the-counter, including vitamins and herbal supplements) that you are taking. Some medicines (such as gold therapy, antimalarial or cancer drugs, oxyphenbutazone or phenylbutazone) should not be used with CUPRIMINE because they also may cause serious liver, kidney, and blood side effects.

Please click here for full Prescribing Information for CUPRIMINE including Boxed Warning

You are encouraged to report negative side effects of prescription drugs to FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.


SYPRINE® (trientine hydrochloride) is used to treat Wilson's disease in patients who cannot take the medication known as penicillamine. Wilson's disease is a condition where the body stores too much copper. Unlike penicillamine, SYPRINE is not recommended to treat cystinuria or rheumatoid arthritis because it is not effective in these conditions, or biliary cirrhosis.



  • Do not take SYPRINE if you are allergic to it.
  • You should remain under regular medical supervision the entire time you are taking SYPRINE.
    • Your doctor should regularly check to see if you have iron deficiency anemia. This is particularly important for women. Your doctor should also check for free copper in your blood.
  • Take SYPRINE on an empty stomach, at least one hour before a meal or two hours after a meal and at least one hour apart from any other drug, food, or milk. The capsules should be swallowed whole with water and should not be opened or chewed.
  • For the first month of treatment, take your temperature every night, and report any symptom such as fever or skin rash to your doctor.
  • Do not take mineral supplements because they may block the absorption of SYPRINE.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are nursing.
  • The following adverse reactions have been reported from a clinical study: iron deficiency and a condition affecting the immune system known as systemic lupus erythematosus. In addition, the following adverse reactions have been reported in marketed use: abnormal or uncontrolled muscle contractions, muscle spasm and an immune disease affecting muscles known as myasthenia gravis.

Please click here for full Prescribing Information for SYPRINE.

You are encouraged to report negative side effects of prescription drugs to FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.